It depends on the form of the Mass. We know that we have Low Masses and Solemn Masses, which is the basic difference. There are different behaviors to be observed in a Solemn Mass than in a Low Mass. In the Low Mass, the Creed is spoken out while standing, and then a genuflection is made during the words "Incarnatus Est" (and he was conceived), then stand again for the rest of the Creed.
In the Solemn Mass, the priest can sit down while the faithful sing the Creed. Sometimes, it could be longer, depending on the Mass. In these cases, the faithful can also sit but have to bow their heads to the words "Incarnatus Est". On Christmas Day or the Annunciation, when singing even while sitting down in the Solemn Mass, the faithful should genuflect on the words "Incarnatus Est".
The posture can also depend on the tradition. In some Solemn Masses, the priest does not sit down during the Creed but stands. You can do both forms, but it also depends on the local tradition.
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